Meglumine: a novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4 H-pyrans

…, RZ Wang, HX Liu, SX Wang, ZH Zhang

文献索引：Guo, Rui-Yun; An, Zhi-Min; Mo, Li-Ping; Wang, Rui-Zhi; Liu, Hong-Xia; Wang, Shu-Xia; Zhang, Zhan-Hui ACS Combinatorial Science, 2013 , vol. 15, # 11 p. 557 - 563

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被引用次数: 68

摘要

An efficient one-pot synthesis of functionalized 2-amino-4 H-pyrans by a meglumine- catalyzed three-component reaction has been developed. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatin derivatives, and acenaphthenequinone are condensed with enolizable C–H activated compounds and alkylmalonates to give the desired products in high to excellent yields. This methodology ...