Tetrahedron Letters

An efficient synthesis of cyanamide from amine promoted by a hypervalent iodine (III) reagent

H Ghosh, R Yella, AR Ali, SK Sahoo, BK Patel

文献索引：Ghosh, Harisadhan; Yella, Ramesh; Ali, Abdur Rezzak; Sahoo, Santosh K.; Patel, Bhisma K. Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2407 - 2410

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被引用次数: 29

摘要

In a one-pot strategy we have achieved an efficient method for the synthesis of organic cyanamides starting from dithiocarbamic acid salts/amines. In this strategy the in situ generated alkyl or aryl isothiocyanates, obtained by the desulfurization of dithiocarbamic acid salts with diacetoxyiodobenzene (DIB) react with aqueous ammonia forming alkyl or aryl thiourea which on subsequent oxidative desulfurization with DIB led to the formation ...