Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors

S Samosorn, JB Bremner, A Ball, K Lewis

文献索引：Samosorn, Siritron; Bremner, John B.; Ball, Anthony; Lewis, Kim Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 3 p. 857 - 865

全文：HTML全文

被引用次数: 99

摘要

In order to develop structure–activity relationships and to provide access to antibacterial agents for dual action studies, a variety of aryl group-substituted 2-aryl-5-nitro-1H-indoles were synthesized and the activity of the compounds assessed as inhibitors of the NorA multidrug resistance pump in the bacterium Staphylococcus aureus. The NorA protein from the major facilitator superfamily of efflux pumps confers resistance to a variety of ...