One-pot conversion of phenols to anilines via Smiles rearrangement

…, BVD Vijaykumar, K Jang, HH Shin, H Zuo, DS Shin

文献索引：Xie, Yong-Sheng; Vijaykumar; Jang, Kiwan; Shin, Hong-Hyun; Zuo, Hua; Shin, Dong-Soo Tetrahedron Letters, 2013 , vol. 54, # 38 p. 5151 - 5154

全文：HTML全文

被引用次数: 6

摘要

Abstract A convenient one-pot synthesis of phenols to anilines using 2-chloroacetamide/K 2 CO 3/DMF system catalyzed by KI via Smiles rearrangement has been described. The synthesis of extensive amino aromatic products from phenols containing electron withdrawing group, has been performed in moderate to excellent yields to demonstrate the potentiality of this method in bio-medicinal and pharmaceutical applications.