A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

…, SE Lawrence, M Brossat, TS Moody, AR Maguire

文献索引：Maguire, Nuala M.; Ford, Alan; Clarke, Sarah L.; Eccles, Kevin S.; Lawrence, Simon E.; Brossat, Maude; Moody, Thomas S.; Maguire, Anita R. Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2144 - 2150

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被引用次数: 4

摘要

The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.