Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related …

…, S Noji, H Yamanaka, Y Hara, H Goto, R Mizojiri…

文献索引：Hirashima, Shintaro; Oka, Takahiro; Ikegashira, Kazutaka; Noji, Satoru; Yamanaka, Hiroshi; Hara, Yoshinori; Goto, Hiroyuki; Mizojiri, Ryo; Niwa, Yasushi; Noguchi, Toru; Ando, Izuru; Ikeda, Satoru; Hashimoto, Hiromasa Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3181 - 3186

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被引用次数: 29

摘要

Following the discovery of JTK-109 (1) as a potent inhibitor of hepatitis C virus NS5B RNA- dependent RNA polymerase,[(a) Hirashima, S.; Suzuki, T.; Ishida, T.; Noji, S.; Yata, S.; Ando, I.; Komatsu, M.; Ikeda, S.; Hashimoto, HJ Med. Chem. 2006, 49, 4721.(b) Hashimoto, H.; Mizutani, K.; Yoshida, A. Int. Patent Appl. WO 01/47883, 2001.] further studies toward the improvement of the cellular potency have been performed. A greater than 40-fold ...