Studies on the biodegradation of fosfomycin: growth of Rhizobium huakuii PMY1 on possible intermediates synthesised chemically

JW McGrath, F Hammerschmidt, W Preusser…

文献索引：McGrath, John W.; Hammerschmidt, Friedrich; Preusser, Werner; Quinn, John P.; Schweifer, Anna Organic and Biomolecular Chemistry, 2009 , vol. 7, # 9 p. 1944 - 1953

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被引用次数: 14

摘要

The first step of the mineralisation of fosfomycin by R. huakuii PMY1 is hydrolytic ring opening with the formation of (1R, 2R)-1, 2-dihydroxypropylphosphonic acid. This phosphonic acid and its three stereoisomers were synthesised by chemical means and tested as their ammonium salts for mineralisation as evidenced by release of Pi. Only the (1R, 2R)-isomer was degraded. A number of salts of phosphonic acids such as (±)-1, 2- ...