Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives

JA Butera, W Spinelli, V Anantharaman…

文献索引：Butera, John A.; Spinelli, Walter; Anantharaman, Viji; Marcopulos, Nicholas; Parsons, Roderick W.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3212 - 3228

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被引用次数: 34

摘要

3 arrhythmias occur in patients suffering from coronary artery disease or from congestive heart failure. These patients constitute most of the population at risk for SCD and their long- term prophylactic treatment is the most challenging goal of antiarrhythmic the rap^.^^^ Cardiac arrhythmias result from abnormalities of either impulse generation, impulse conduction, or a combination of both! Several different mechanisms underlie each type of ...

4760-35-4

2-(氯甲基)-1-甲基-1H-苯并咪唑

~87%

~88%

~78%

~40%

~72%

~34%

~84%

~91%

~56%

~82%

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