Synthèse générale et efficace de β-cétophosphonates

P Coutrot, C Grison, M Lachgar, A Ghribi

文献索引：Coutrot, Philippe; Grison, Claude; Lachgar, Mohamed; Ghribi, Abdelaziz Bulletin de la Societe Chimique de France, 1995 , vol. 132, p. 925 - 942

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被引用次数: 9

摘要

Résumé/Abstract The acylation of organocuprates or organolithiated reagents with 2- dialkylphosphonoalkanoyl chlorides or dialkylphosphonofluoroacetyl chlorides represents a general and efficient route to β-ketophosphonates. A Horner reaction between the lithiated anions derived from α-fluoro-β-ketophosphonates and aldehydes leads to 2-fluoro-2-enones whereas the lithiated anions derived from γ-acetylenic-β-ketophosphonates afford ...