Structure–activity relationships of acyloxyamidine cytomegalovirus DNA polymerase inhibitors

…, MW Schulz, LE Harrington, SJ Conrad, Y Yagi…

文献索引：Tucker, John A.; Clayton, Terrance L.; Chidester, Connie G.; Schulz, Martin W.; Harrington, Leigh E.; Conrad, Steven J.; Yagi, Yoshihiko; Oien, Nancee L.; Yurek, David; Kuo, Ming-Shang Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 601 - 615

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被引用次数: 31

摘要

This paper describes the structure–activity relationships of a new class of cytomegalovirus DNA polymerase inhibitors having two aryl groups joined by an acyloxyamidine linker. Examination of a series of analogues in which the terminal groups are varied revealed a very narrow SAR around the 2, 4-dichlorophenyl group of the lead compound, but a variety of replacements for the benzothiazole ring are compatible with activity. The most notable ...