Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles

J Einsiedel, C Thomas, H Hübner, P Gmeiner

文献索引：Einsiedel, Juergen; Thomas, Christoph; Huebner, Harald; Gmeiner, Peter Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2041 - 2044

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被引用次数: 31

摘要

In order to recognize the essential structural features of the systems we were intrigued by the question whether oxazole or thiazole moieties could be employed as an alternative with substantially different electronic properties being, furthermore, devoid of a H-donating group. These deliberations led us to compounds of type 4 when we planned to incorporate N-phenylpiperazinylmethyl, N-benzylpiperazinylmethyl or N-benzylpiperidinylaminomethyl side chains. In order to ...