Novel benzofuroxan derivatives against multidrug-resistant Staphylococcus aureus strains: design using Topliss' decision tree, synthesis and biological assay

…, F Palace-Berl, A Masunari, CA Cechinel, M Ishii…

文献索引：Jorge, Salomao Doria; Palace-Berl, Fanny; Masunari, Andrea; Cechinel, Cleber Andre; Ishii, Marina; Pasqualoto, Kerly Fernanda Mesquita; Tavares, Leoberto Costa Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 5031 - 5038

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被引用次数: 16

摘要

The aim of this study was the design of a set of benzofuroxan derivatives as antimicrobial agents exploring the physicochemical properties of the related substituents. Topliss' decision tree approach was applied to select the substituent groups. Hierarchical cluster analysis was also performed to emphasize natural clusters and patterns. The compounds were obtained using two synthetic approaches for reducing the synthetic steps as well as ...