The Stobbe Condensation with Tetralone-1. A Synthesis of 3'-Keto-3, 4-dihydro-1, 2-cyclopentenonaphthalene1

WS Johnson, HCE Johnson…

文献索引：Johnson; Johnson; Petersen Journal of the American Chemical Society, 1945 , vol. 67, p. 1360,1364

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被引用次数: 11

摘要

Summary Potassium t-butoxide has been found to be an excellent agent for promoting the Stobbe condensation of a ketone with diethyl succinate. Procedures are given for the introduction of a propionic acid residue at the site of the carbonyl group of an aryl ketone. The steps involve (1) a Stobbe condensation with potassium t-butoxide,(2) acid-catalyzed decarbethoxylation of the resulting half-ester and (3) reduction. An application of the ...