Tetrahedron

Microwave-assisted synthesis of indole-and azaindole-derivatives in water via cycloisomerization of 2-alkynylanilines and alkynylpyridinamines promoted by amines …

A Carpita, A Ribecai, P Stabile

文献索引：Carpita, Adriano; Ribecai, Arianna; Stabile, Paolo Tetrahedron, 2010 , vol. 66, # 35 p. 7169 - 7178

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被引用次数: 36

摘要

An efficient methodology is described and exploited for the preparation of differently substituted indoles and azaindoles via microwave-assisted cycloisomerization in water of 2- alkynylanilines and alkynylpyridinamines, which is promoted by catalytic amounts of neutral or basic salts or by stoichiometric weak organic bases. Good to high yields in the cyclization can be achieved for a variety of 2-amino (hetero) aryl alkynes. Reactions are run without ...