Enantiodivergent syntheses of (+)-and (-)-nonactic acid and the total synthesis of nonactin

PA Bartlett, JD Meadows, E Ottow

文献索引：Bartlett; Meadows; Ottow Journal of the American Chemical Society, 1984 , vol. 106, # 18 p. 5304 - 5311

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被引用次数: 136

摘要

Abstract: The crystalline (S)-(-)-epoxy tosylate 16 is prepared in 76% overall yield from dimethyl (S)-(-)-malate. Reaction of this material with lithium dimethylcyanocuprate affords (S)-(-)-1, 7-octadien-4-01 ((-)-17). Iodocyclization of the tert-butyl carbonate (-)-6 and ...