An efficient and alternative synthesis of enantiomerically pure (+)-(S)-4-(4-((4- chlorophenyl)(pyrid-2-yl) methoxy] piperidin-1-yl) butanoic acid, bepotastine (1) is described. The key resolution of (R/S)-bepotastine l-menthyl ester (3) is achived via diastereomeric salt crystallization using N-benzyloxycarbonyl-L-aspartic acid (NCbzLAA) as the resolving agent to provide (S)-bepotastine l-menthyl ester (S)-3. Hydrolysis of (S)- ...
