Tetrahedron

Comparative study of synthetic approaches to 1-arylmethylenepyrazino [2, 1-b] quinazoline-3, 6-diones

P Cledera, C Avendaño, JC Menéndez

文献索引：Cledera, Pilar; Avendano, Carmen; Menendez, J. Carlos Tetrahedron, 1998 , vol. 54, # 40 p. 12349 - 12360

全文：HTML全文

被引用次数: 35

摘要

The transformation of 3-arylmethylenepiperazine-2, 5-diones (1) into 1-arylmethylene-2, 4- dihydro-1H-pyrazino [2, 1-b] quinazoline-3, 6-diones (2) was studied. Four synthetic methods were compared, namely direct condensation with the product of the reaction between anthranilic acid and thionyl chloride, transformation into monothioiminoethers or monoiminoethers followed by reaction with anthranilic acid derivatives, and ...