Promiscuous Behavior of Rhizomucor miehei Lipase in the Synthesis of N??Substituted β??Amino Esters

…, F Gillanders, A Baldessari

文献索引：Monsalve, Leandro N.; Gillanders, Florencia; Baldessari, Alicia European Journal of Organic Chemistry, 2012 , # 6 p. 1164 - 1170

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被引用次数: 14

摘要

Abstract A mild and efficient procedure for the aza-Michael addition of amines to acrylates by using lipases as catalysts is reported. Various lipases, mono-and bifunctional amines, alkyl acrylates, and reaction parameters were studied. Under the optimal conditions, Rhizomucor miehei lipase showed high selectivity. It catalyzed the formation of the Michael monoadduct as the only product in high yield and purity. Moreover, when diamines were used as ...