Dodecanoic acid derivatives: synthesis, antimicrobial evaluation and development of one-target and multi-target QSAR models

…, A Kapoor, R Narang, V Judge, B Narasimhan

文献索引：Sarova, Devinder; Kapoor, Archana; Narang, Rakesh; Judge, Vikramjeet; Narasimhan, Balasubramanian Medicinal Chemistry Research, 2011 , vol. 20, # 6 p. 769 - 781

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被引用次数: 7

摘要

Abstract In this study a series of dodecanoic acid derivatives (1–30) were synthesized and evaluated for in vitro antimicrobial activity against the panel of Gram positive, Gram negative bacterial and fungal strains. 4-Nitro phenyl dodecanoate (4) and quinolin-8-yl dodecanoate (5) emerged as most effective antibacterial agents, and 1-(4-benzylpiperazin-1-yl) dodecan- 1-one (15) was found to be the most effective antifungal agent amongst the synthesized ...