1-[2-(2-Hydroxymethylphenylthio) benzyl]-4-methylpiperzine and related compounds as potential antidepressants: Synthesis and pharmacological acreening

I Červená, M Protiva

文献索引：Cervena, Irena; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 4 p. 1009 - 1020

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摘要

Abstract Heating of 1-(2-iodobenzoyl)-4-methylpiperazine (II) with thiophenol and its 2- methyl, 4-methyl, 4-chloro and 2-hydroxymethyl derivatives in dimethylformamide in the presence of potassium carbonate, copper and cuprous iodide gave the piperazides IV-VIII; compound VIII was transformed by reduction with lithium aluminium hydride to the title compound I. The acid IX, obtained by a reaction of 5-chloro-2-iodobenzoic acid with 2- ...