Decomposition of N-phosphorylated nitrogen mustards: a mechanistic investigation

C le Roux, AM Modro, TA Modro

文献索引：Roux, Charlotte le; Modro, Agnes M.; Modro, Tomasz A. Journal of Organic Chemistry, 1995 , vol. 60, # 12 p. 3832 - 3839

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被引用次数: 13

摘要

Lithium methyl N-(2-chloroethyl) phosphoramidate (2b) and lithium methyl N, N-bis (2- chloroethyl)-phosphoramidate (2c) were prepared as models of N-phosphorylated mustards used in cancer chemotherapy. The decomposition of those substrates in DzO and in DzO- pyridine-d6 was studied to elucidate the mechanism of their alkylating reactivity. The products of the decomposition and the variation of the proportions of the products with ...