Functionalized Benzylic Magnesium Reagents through a Sulfur–Magnesium Exchange

AH Stoll, A Krasovskiy, P Knochel

文献索引：Stoll, Armin H.; Krasovskiy, Arkady; Knochel, Paul Angewandte Chemie - International Edition, 2006 , vol. 45, # 4 p. 606 - 609

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被引用次数: 47

摘要

The required thiosulfonates 2 were prepared either by the reaction of PhSO2Na with disulfides [7] or by the reaction of PhSO2SNa with various benzylic halides in N, N- dimethylformamide [8](see Supporting Information). Alternatively, the benzylic o-(o- iodophenyl) phenylthio derivatives 1 can also be synthesized from 4 through the two-step preparation of the chloromethyl thioether 5, which was obtained in 72% overall yield.[9] ...