Reaction of β??dimethylaminovinyl ketones with hydroxylamine: A simple and useful method for synthesis of 3??and 5??substituted isoxazoles

…, P Machado, HG Bonacorso, N Zanatta…

文献索引：Rosa, Fernanda A.; Machado, Pablo; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A. P. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 3 p. 879 - 885

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被引用次数: 30

摘要

The synthesis of isoxazole and its derivatives has been a subject of continuous interest because of the numerous applications for such heterocycles in the pharmaceutical and agrochemical industry [1]. Recently, these compounds have been found to be an integral part of the selective inhibitors of the transglutaminase human 2 being thus important prototypes for treatment of Huntington's, Alzheimer's, and Parkinson's diseases [2]. Other ...