... To do so, tretinoin must block the induction of matrix metalloproteinases in the dermis. ... 8. Uitto J. Collagen. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, eds. Dermatology in general medicine. 4th ed. Vol. ... FASEB J 1995;9:974-980 Web of Science | Medline. 26. ...