Chemistry Letters

Novel asymmetric alkylation of cyclic. BETA.-keto esters with optically active sulfonium salts.

…, K Umemura, N Watanabe, H Matsuyama

文献索引：Kobayashi, Michio; Umemura, Kazuyuki; Watanabe, Nobuko; Matsuyama, Haruo Chemistry Letters, 1985 , p. 1067 - 1070

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被引用次数: 17

摘要

A new asymmetric alkylation of cyclic β-keto esters with optically active sulfonium salts, which are easily prepared by optical resolution methods, has been investigated. Relative reactivities for alkyl substituents are found to be quite different from those for SN 2 alkylation. Stereochemical reaction course via S–O sulfurane intermediate for this new reaction is proposed.