Steroids

Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

…, P García, Y Heuze, J Soriano, A Mejía, AM Labastida…

文献索引：Bratoeff, Eugene; Garcia, Perla; Heuze, Yvonne; Soriano, Juan; Mejia, Adriana; Labastida, Ana Maria; Valencia, Norma; Cabeza, Marisa Steroids, 2010 , vol. 75, # 7 p. 499 - 505

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被引用次数: 12

摘要

The aim of this study was to ascertain the inhibitory effect of several progesterone derivatives for 5α-reductase types 1 and 2 isozymes and to determine the binding to the androgen receptor. The 3, 20-dioxopregna-4-ene-17α-yl acetate 4 containing an acetoxy group in C-17 and steroid 17α-hydroxypregn-4-ene-3, 20-dione 5 having a hydroxyl group in the same position inhibited both isozymes. On the other hand, 17α-hydroxy-4, 5- ...