Sila-biperiden undendo-Sila-biperiden: Synthesen, Kristallstrukturen und antimuscarinische Eigenschaften

R Tacke, J Pikies, F Wiesenberger, L Ernst…

文献索引：Tacke, Reinhold; Pikies, Jerzy; Wiesenberger, Frank; Ernst, Ludger; Schomburg, Dietmar; et al. Journal of Organometallic Chemistry, 1994 , vol. 466, # 1-2 p. 15 - 28

全文：HTML全文

被引用次数: 14

摘要

Summary Starting from trichloro (vinyl) silane (Cl 3 SiCH= CH 2), the muscarinic antagonists sila-biperiden [rac-(SiRS, C2SR)-exo-2] andendo-sila-biperiden [rac-(SiRS, C2SR)-endo-2] were prepared by a seven-step synthesis. Both silanols are configurationally stable in inert organic solvents but undergo slow epimerization in aqueous solution (pH 7.4, 32 C) by inversion of the configuration at the silicon atom. The relative configurations of sila- ...