Comparison of biological effects of N-alkylated congeners of. beta.-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene

JG Cannon, JA Perez, JP Pease, JP Long…

文献索引：Cannon, Joseph G.; Perez, Julio A.; Pease, Jonathan P; Long, John Paul; Flynn, Jan R.; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 745 - 749

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被引用次数: 32

摘要

Three series of bicyclic, semirigid congeners of@-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions. Pharmacologic activity was associated with 2-aminotetralin and 8-aminoindan derivatives, but was not found with 6-aminobenzocycloheptene derivatives. Noteworthy is the ability of ...