Synthesis and properties of oligo-2′-deoxyribonucleotides containing internucleotidic phosphoramidate linkages modified with pendant groups ending with either …

U Asseline, M Chassignol, J Draus, M Durand…

文献索引：Asseline, Ulysse; Chassignol, Marcel; Draus, Jolanta; Durand, Maurice; Maurizot, Jean-Claude Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 16 p. 3499 - 3511

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被引用次数: 21

摘要

Single and multiple incorporations of stereochemically pure modified dinucleoside- phosphoramidates involving substituent groups ending with bis-hydroxyethyl and bis- aminoethyl groups have been performed into pyrimidic triple helix-forming oligo-2′- deoxyribonucleotides designed to bind parallel to the purine strand of the DNA target. The ability of these modified oligo-2′-deoxyribonucleotides to form triple helices has been ...