Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs

L Guandalini, E Martini, LDC Mannelli, S Dei…

文献索引：Guandalini; Martini; Di Cesare Mannelli; Dei; Manetti; Scapecchi; Teodori; Ghelardini; Romanelli Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1936 - 1939

全文：HTML全文

被引用次数: 6

摘要

A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most ...