ChemMedChem

Design, synthesis and structure–activity relationships studies on the D ring of the natural product triptolide

H Xu, H Tang, H Feng, Y Li

文献索引：Xu, Hongtao; Tang, Huanyu; Feng, Huijin; Li, Yuanchao ChemMedChem, 2014 , vol. 9, # 2 p. 290 - 295

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被引用次数: 7

摘要

Triptolide is a diterpene triepoxide natural product isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal herb. Triptolide has previously been shown to possess antitumor, anti-inflammatory, immunosuppressive, and antifertility activities. Earlier reports suggested that the five-membered unsaturated lactone ring (D ring) is essential for potent cytotoxicity, however, to the best of our knowledge, systematic structure–activity relationship studies ...