Site-directed chemical mutations on abzymes: large rate accelerations in the catalysis by exchanging the functionalized small nonprotein components

…, T Hirokawa, T Tsumuraya, I Fujii

文献索引：Ishikawa, Fumihiro; Tsumuraya, Takeshi; Fujii, Ikuo Journal of the American Chemical Society, 2009 , vol. 131, p. 456 - 457

全文：HTML全文

被引用次数: 0

摘要

Taking advantage of antibody molecules to generate tailor-made binding sites, we propose a new class of protein modifications, termed as “site-directed chemical mutation.” In this modification, chemically synthesized catalytic components with a variety of steric and electronic properties can be noncovalently and nongenetically incorporated into specific sites in antibody molecules to induce enzymatic activity. Two catalytic antibodies, 25E2 ...