Mass spectrometric characterization of activated N??(2??chloroethyl) amido oxazaphosphorine derivatives

M Przybylski, H Ringsdorf, U Lenssen…

文献索引：Przybylski; Ringsdorf; Lenssen; Peter; Voelcker; Wagner; Hohorst Biomedical mass spectrometry, 1977 , vol. 4, # 4 p. 209 - 215

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被引用次数: 17

摘要

Abstract The hydroperoxy and several alkylthio derivatives of the antitumor agents cyclophosphamide (2-bis (2-chloroethyl) amino tetrahydro-2H-1, 3, 2-oxazaphosphorine 2- oxide), ifosfamide (3-(2-chloroethyl)-2-(2-chloroethylamino) tetrahydro-2H-1, 3, 2- oxazaphosphorine 2-oxide) and trofosfamide (3-(2-chloroethyl)-2-(bis (2-chloroethyl) amino) tetrahydro-2H-1, 3, 2-oxazaphosphorine 2-oxide) were characterized by electron impact ...