Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

…, W Wang, SL Gwaltney, TW Rockway…

文献索引：Hasvold, Lisa A.; Wang, Weibo; Gwaltney II, Stephen L.; Rockway, Todd W.; Nelson, Lissa T. J.; Mantei, Robert A.; Fakhoury, Stephen A.; Sullivan, Gerard M.; Li, Qun; Lin, Nan-Horng; Wang, Le; Zhang, Haiying; Cohen, Jerome; Gu, Wen-Zhen; Marsh, Kennan; Bauch, Joy; Rosenberg, Saul; Sham, Hing L. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 4001 - 4005

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被引用次数: 45

摘要

Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.