Thiol additions to acrylates by fluorous mixture synthesis: relative control of elution order in demixing by the fluorous tag and the thiol substituent
DP Curran, Y Oderaotoshi
文献索引：Curran, Dennis P.; Oderaotoshi, Yoji Tetrahedron, 2001 , vol. 57, # 24 p. 5243 - 5253
All possible combinations of a series of three fluorous benzyl tags and three acrylates have been made. The resulting acrylate esters were combined in groups of three (one of each tag) and the resulting mixtures were reacted with a mixture of four thiols under standard conditions to effect conjugate addition. Analysis of the resulting libraries by fluorous hplc showed a primary separation based on the tag and revealed reliable secondary ...
