Tetrahedron

The synthesis of fluorine-containing pterins

C Dunn, CL Gibson, CJ Suckling

文献索引：Dunn, Caroline; Gibson, Colin L.; Suckling, Colin J. Tetrahedron, 1996 , vol. 52, # 40 p. 13017 - 13026

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被引用次数: 22

摘要

The synthesis of some 7, 7-difluoro-7, 8-dihydropterins and pterins with fluoroalkyl subsitutents at the 6 or 7 positions from fluorine-containing aliphatic precursors and suitably substituted pyrimidines is described. The fluorine-containing pterins were found to be very insoluble and also stable to nucleophiles and bases in dilute aqueous solution.