Tetrahedron

Regioselective ortho-hydroxylation of 2-arylbenzothiazole via substrate directed C–H activation

A Banerjee, A Bera, S Guin, SK Rout, BK Patel

文献索引：Banerjee, Arghya; Bera, Anupam; Guin, Srimanta; Rout, Saroj Kumar; Patel, Bhisma K. Tetrahedron, 2013 , vol. 69, # 9 p. 2175 - 2183

全文：HTML全文

被引用次数: 28

摘要

An efficient protocol has been developed for the direct ortho-hydroxylation of 2- arylbenzothiazole using Pd (OAc) 2 as the catalyst and either of DIB/AcOH or Oxone®/TFA combinations under air atmosphere. Under both these conditions, the methodology tolerates a diverse array of substituents giving good to excellent yields of corresponding ortho- hydroxylated products. Regioselective hydroxylation is observed at the less sterically ...