前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Benzotriazole-assisted synthesis of novel mannich bases from ketones and diverse aldehydes

AR Katritzky, PA Harris

文献索引：Katritzky, Alan R.; Harris, Philip A. Tetrahedron, 1990 , vol. 46, # 3 p. 987 - 996

全文：HTML全文

被引用次数: 50

摘要

A wide variety of β-amino ketones are prepared in moderate to good yields by the reaction of the lithium enolates of cyclohexanone, acetophenone, α-tetralone and camphor with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Some diastereoselectivity is observed when the benzotriazole adduct is derived from benzaldehyde.

(4-MORPHOLINYLPHENYLMETHYL)BENZOTRIAZOL&结构式

(4-MORPHOLINYLP...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~46%

1,3,5-三苯基-1,5-戊二酮结构式

1,3,5-三苯基-1,5-戊二酮

苯并三氮唑结构式

苯并三氮唑

N-苯基苯并三唑甲胺,Bt1和Bt2异构体的混合物结构式

N-苯基苯并三唑甲胺,Bt1和...

未登录结构式

~0%

苯并三氮唑结构式

苯并三氮唑

2-((phenylamino)methyl)cyclohexanone结构式

2-((phenylamino...

N-(1H-苯并三唑-1-基甲基)苯甲酰胺结构式

N-(1H-苯并三唑-1-基甲...

未登录结构式

~0%

苯并三氮唑结构式

苯并三氮唑

N-[(2-oxocyclohexyl)methyl]benzamide结构式

N-[(2-oxocycloh...

1-(piperidin-1-ylmethyl)benzotriazole结构式

1-(piperidin-1-...

未登录结构式

~0%

苯并三氮唑结构式

苯并三氮唑

哌美克隆结构式

1-(1-morpholinocyclohexyl)-1H-1,2,3-benzotriazole结构式

1-(1-morpholino...

未登录结构式

~0%

苯并三氮唑结构式

苯并三氮唑

2-(1-morpholinocyclohexyl)cyclohexanone结构式

2-(1-morpholino...

N-苯基苯并三唑甲胺,Bt1和Bt2异构体的混合物结构式

N-苯基苯并三唑甲胺,Bt1和...

lithium enolate of 1-tetralone结构式

lithium enolate...

~0%

苯并三氮唑结构式

苯并三氮唑

3,4-dihydro-2-(phenylaminomethyl)-1-naphthalenone结构式

3,4-dihydro-2-(...

详细

(4-MORPHOLINYLPHENYLMETHYL)BENZOTRIAZOL&结构式

(4-MORPHOLINYLP...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

1,3,5-三苯基-1,5-戊二酮结构式

1,3,5-三苯基-1,5-戊二酮

苯并三氮唑结构式

苯并三氮唑

1-(1-morpholinocyclohexyl)-1H-1,2,3-benzotriazole结构式

1-(1-morpholino...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

苯并三氮唑结构式

苯并三氮唑

Ethanone,2-cyclohexylidene-1-phenyl-结构式

Ethanone,2-cycl...

详细

N-苯基苯并三唑甲胺,Bt1和Bt2异构体的混合物结构式

N-苯基苯并三唑甲胺,Bt1和...

lithium 1,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-olate结构式

lithium 1,7,7-t...

~0%

苯并三氮唑结构式

苯并三氮唑

1,7,7-trimethyl-3-(phenylaminomethyl)-bicyclo(2.2.1)heptan-2-one结构式

1,7,7-trimethyl...

1-(piperidin-1-ylmethyl)benzotriazole结构式

1-(piperidin-1-...

lithium 1,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-olate结构式

lithium 1,7,7-t...

~0%

苯并三氮唑结构式

苯并三氮唑

1,7,7-trimethyl-3-(piperidinomethyl)-bicyclo(2.2.1)heptan-2-one结构式

1,7,7-trimethyl...

1-(piperidin-1-ylmethyl)benzotriazole结构式

1-(piperidin-1-...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

苯并三氮唑结构式

苯并三氮唑

1-phenyl-3-piperidin-1-yl-2-(piperidin-1-ylmethyl)propan-1-one结构式

1-phenyl-3-pipe...

详细

N-苯基苯并三唑甲胺,Bt1和Bt2异构体的混合物结构式

N-苯基苯并三唑甲胺,Bt1和...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

苯并三氮唑结构式

苯并三氮唑

1-Propanone,1-phenyl-3-(phenylamino)-结构式

1-Propanone,1-p...

N-(1H-苯并三唑-1-基甲基)苯甲酰胺结构式

N-(1H-苯并三唑-1-基甲...

未登录结构式

~0%

苯并三氮唑结构式

苯并三氮唑

N-[(2-oxocyclohexyl)methyl]benzamide结构式

N-[(2-oxocycloh...

详细

1-(2-吗啉-4-乙基)-1H-苯并噻唑结构式

1-(2-吗啉-4-乙基)-1...

未登录结构式

~%

苯并三氮唑结构式

苯并三氮唑

2-(1-morpholinoethyl)cyclohexanone结构式

2-(1-morpholino...

未登录结构式

未登录结构式

~%

苯并三氮唑结构式

苯并三氮唑

未登录结构式

N-[α-(benzotriazol-1-yl)phenylmethyl]piperidine结构式

N-[α-(benzotria...

未登录结构式

~%

苯并三氮唑结构式

苯并三氮唑

2-苯亚甲基环己酮结构式

2-苯亚甲基环己酮

详细

1-(1-morpholinocyclohexyl)-1H-1,2,3-benzotriazole结构式

1-(1-morpholino...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

苯并三氮唑结构式

苯并三氮唑

Ethanone,2-cyclohexylidene-1-phenyl-结构式

Ethanone,2-cycl...

详细

1-(piperidin-1-ylmethyl)benzotriazole结构式

1-(piperidin-1-...

未登录结构式

~67%

苯并三氮唑结构式

苯并三氮唑

哌美克隆结构式

N-苯基苯并三唑甲胺,Bt1和Bt2异构体的混合物结构式

N-苯基苯并三唑甲胺,Bt1和...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~9%

苯并三氮唑结构式

苯并三氮唑

1-Propanone,1-phenyl-3-(phenylamino)-结构式

1-Propanone,1-p...

1-(piperidin-1-ylmethyl)benzotriazole结构式

1-(piperidin-1-...

lithium 1-phenylethenolate结构式

lithium 1-pheny...

~0%

苯并三氮唑结构式

苯并三氮唑

1-phenyl-3-piperidin-1-yl-2-(piperidin-1-ylmethyl)propan-1-one结构式

1-phenyl-3-pipe...

详细

N-(1H-苯并三唑-1-基甲基)苯甲酰胺结构式

N-(1H-苯并三唑-1-基甲...

未登录结构式

~87%

苯并三氮唑结构式

苯并三氮唑

N-[(2-oxocyclohexyl)methyl]benzamide结构式

N-[(2-oxocycloh...

N-(1H-苯并三唑-1-基甲基)苯甲酰胺结构式

N-(1H-苯并三唑-1-基甲...

未登录结构式

~13%

苯并三氮唑结构式

苯并三氮唑

N-[(2-oxocyclohexyl)methyl]benzamide结构式

N-[(2-oxocycloh...

详细

1, 5-Diketone synthesis promoted by barium hydride or barium...

[Takahashi, Hiroshi; Arai, Takayoshi; Yanagisawa, Akira Synlett, 2006 , # 17 p. 2833 - 2835]

Aluminum Bis (trifluoromethylsulfonyl) amides: New Highly Ef...

[Marx, Andreas; Yamamoto, Hisashi Angewandte Chemie - International Edition, 2000 , vol. 39, # 1 p. 178 - 181]

Gold (III)-mediated aldol condensations provide efficient ac...

[Waldmann, Herbert; Karunakar, Galla V.; Kumar, Kamal Organic Letters, 2008 , vol. 10, # 11 p. 2159 - 2162]

Gold (III)-mediated aldol condensations provide efficient ac...

[Waldmann, Herbert; Karunakar, Galla V.; Kumar, Kamal Organic Letters, 2008 , vol. 10, # 11 p. 2159 - 2162]

SmI3 mediated reginospecific Michael addition of ω-bromo-ace...

[Zheng, Xingliang; Zhang, Yongmin Journal of Chemical Research, 2004 , # 6 p. 412 - 413]