Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors, Part 1. N-(Phenylpropyl)-1-arylethylamines

…, J Ong, MV Perkins, RH Prager, NM Puspawati

文献索引：Kerr, David I. B.; Ong, Jennifer; Perkins, Michael V.; Prager, Rolf H.; Puspawati, Ni Made Australian Journal of Chemistry, 2006 , vol. 59, # 7 p. 445 - 456

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被引用次数: 12

摘要

Abstract A series of 15 analogues of fendiline, and 34 derivatives of N-(3-phenylpropyl)-1- arylethylamine have been prepared for evaluation as positive allosteric modulators of GABA B receptors. The most active (EC 50, 10 nM) was N-(3, 3-diphenylpropyl)-1-(3-chloro-4- methoxyphenyl) ethylamine 6g.