A Practical Synthesis of 3, 4-Diethoxybenzthioamide Based on Friedel–Crafts Reaction with Potassium Thiocyanate in Methanesulfonic Acid

S Aki, T Fujioka, M Ishigami, J Minamikawa

文献索引：Aki, Shinji; Fujioka, Takafumi; Ishigami, Masashi; Minamikawa, Jun-ichi Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2317 - 2320

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被引用次数: 9

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel–Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature. ... 6-[2-(3,4-Diethoxyphenyl)thiazol-4-yl]pyridine-2- ...