Tetrahedron letters

Short-step synthesis of amino acids and N-hydroxyamino acids from amines

SI Murahashi, T Shiota

文献索引：Murahashi, Shun-Ichi; Shiota, Tatsuki Tetrahedron Letters, 1987 , vol. 28, # 51 p. 6469 - 6472

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被引用次数: 40

摘要

Catalytic oxidation of secondary amines with hydrogen peroxide followed by treatment with hydrogen cyanide gave α-cyanohydroxylamines ( ). Hydrolysis of gave N-hydroxyamino acids ( ), which undergo catalytic hydrogenation to give amino acids ( ). This is a simple, efficient and inexpensive method for synthesis of amino acids from amines. ... Catalytic oxidation of secondary amines with hydrogen peroxide followed by treatment with hydrogen cyanide gives α- ...