Tetrahedron letters

A method for the facile synthesis of ring-A hydroxylated flavones

M Cushman, D Nagarathnam

文献索引：Cushman, Mark; Nagarathnam, Dhanapalan Tetrahedron Letters, 1990 , vol. 31, # 45 p. 6497 - 6500

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被引用次数: 35

摘要

Abstract A general method for the facile synthesis of ring-A hydroxylated flavones is described. Treatment of the hydroxylated acetophenones 6a–d with enough lithium bis (trimethyl) silyl amide to deprotonate all of the phenols as well as to generate the lithium enolate of the ketone, followed by addition of the acid chlorides 7a–d, gave the 1, 3- diketones 8a–g, which were cyclized to the desired products 9a–g in high yield.