4-[2-(Di-n-propylamino) ethyl]-2 (3H)-indolone: a prejunctional dopamine receptor agonist

G Gallagher Jr, PG Lavanchy, JW Wilson…

文献索引：Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536

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被引用次数: 66

摘要

4-[2-(Di-n-propylamino) ethyl]-2 (3H)-indolone (IC)(SK&F 101468) is a potent and selective prejunctional dopamine receptor agonist. It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (ECW= 100 nM), and this response was antagonized by (S)-sulpiride (KB= 7 nM). Compound IC did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce ...