Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors

…, S Margosiak, S Chu, VA Feher, R Almassy…

文献索引：Tedder, Martina E.; Nie, Zhe; Margosiak, Stephen; Chu, Shaosong; Feher, Victoria A.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3165 - 3168

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被引用次数: 29

摘要

The structure-based design, synthesis, and biological activity of novel inhibitors of S- adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and ...