Synthesis, structure and anti-fungal activity of 3-(2′-nitrovinyl) Indoles

…, JA Escario, I Jimenez, AR Martinez-Fernandez

文献索引：Canoira; Gonzalo Rodriguez; Subirats; Escario; Jimenez; Martinez-Fernandez European Journal of Medicinal Chemistry, 1989 , vol. 24, # 1 p. 39 - 42

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被引用次数: 40

摘要

Abstract 3-(2′-Nitrovinyl) indoles 7—18 have been prepared in good yields by condensation of 3-formylindoles with nitroalkanes. Analyses of 1 H NMR data suggest that the indolic system has an extended conjugation through the ethylene double bond and the nitro group. 3-(2′-Methyl-2′-nitrovinyl) indole 9 and 2-methyl-3-(2′-methyl-2′-nitrovinyl) indole 13 show anti-fungal activity against Candida albicans similar to that of ...