An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator

…, C Madhu, TM Vishwanatha, VV Sureshbabu

文献索引：Nagendra; Madhu; Vishwanatha; Sureshbabu, Vommina V. Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5059 - 5063

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被引用次数: 20

摘要

A simple and efficient method for the synthesis of alcohols from the corresponding carboxylic acids is described. Activation of carboxylic acid with 1-propanephosphonic acid cyclic anhydride (T3P) and subsequent reduction using NaBH4 yield the alcohol in excellent yields with good purity. Reduction of several alkyl/aryl carboxylic acids and Nα-protected amino acids/peptide acids as well as Nβ-protected amino acids was successfully carried ...