A highly efficient methodology for 5??methyl??3??aryl??2??thiooxazolidin??4??ones using lithium perchlorate in DIPEA mediated synthesis

GL Khatik, A Pal, TD Apsunde…

文献索引：Khatik, Gopal L.; Pal, Anang; Apsunde, Tushar D.; Nair, Vipin A. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 734 - 739

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被引用次数: 9

摘要

Oxazolidinones and thiooxazolidinones form an integral part of many drugs/intermediates [1, 2]. They are well known as chiral directing agents in asymmetric synthesis [3, 4]. Thiooxazolidinones were reported for various activities such as potassium channel openers [5], antidiabetics [2], and anticonvulsants [6]. A perusal of the literature shows that there is no report on the synthesis of 3-aryl-2-thiooxazolidin-4-ones having an a-proton, and the ...