CeCl3· 7H2O: An effective additive in Ru-catalyzed enantioselective hydrogenation of aromatic α-ketoesters

Q Meng, Y Sun, V Ratovelomanana-Vidal…

文献索引：Meng, Qinghua; Sun, Yanhui; Ratovelomanana-Vidal, Virginie; Genet, Jean Pierre; Zhang, Zhaoguo Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3842 - 3847

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被引用次数: 54

摘要

In the presence of catalytic amounts of CeCl3· 7H2O,[RuCl (benzene)(S)-SunPhos] Cl is a highly effective catalyst for the asymmetric hydrogenation of aromatic α-ketoesters. A variety of ethyl α-hydroxy-α-arylacetates have been prepared in up to 98.3% ee with a TON up to 10 000. Challenging aromatic α-ketoesters with ortho substituents are also hydrogenated with high enantioselectivities. The addition of CeCl3· 7H2O not only improves the ...