Synthesis of 4??Substituted??and 1, 4??Disubstituted??4??hydroxypyrrolidin??2??ones

CR Kinsinger, CD Tatko, CM Whelan…

文献索引：Kinsinger, Christopher R.; Tatko, Chad D.; Whelan, Christopher M.; Wilkinson, Timothy J. Synthetic Communications, 2007 , vol. 37, # 11 p. 1845 - 1852

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被引用次数: 2

摘要

This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin ??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate. ... This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate.