A safe, convenient and efficient method for the preparation of heterocyclic N-oxides using urea· hydrogen peroxide

…, VA Phillips, RS Rubio, MÁ Castro, RT Wheelhouse

文献索引：Rong, Dawen; Phillips, Victoria A.; Rubio, Ramon Sanchez; Angeles Castro, Ma; Wheelhouse, Richard T. Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6933 - 6935

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被引用次数: 28

摘要

A novel, convenient, and high-yielding method has been developed for the preparation of heterocyclic N-oxides. The reaction uses the urea· hydrogen peroxide addition complex as a peroxide source for the in situ generation of trifluoroperacetic acid. The advantages of this method are easy handling of a stable, solid oxidant; high yields and simple removal of excess reagents and by-products.